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Article

Age at Menarche and Coronary Artery Disease Risk: Divergent Associations With Different Sources of Variation.

The Journal of clinical endocrinology and metabolism - 16 Oct 2025

Sonawalla Ambreen, Chasman Daniel I, Chan Yee-Ming

Abstract excerpt

BACKGROUND: In women, both earlier and later age at menarche (AAM) are associated with increased risk of coronary artery disease (CAD). This study examined if the relationship of AAM with CAD and CAD risk factors differs for different underlying sources of variation in AAM-specifically, variation that is attributable to common genetic variants, as represented by a polygenic score (PGS), vs variation in AAM that...

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Identifiers

PMID: 40059721
DOI: 10.1210/clinem/dgaf141
PMCID: PMC12527448

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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