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Integrated Single‐Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease

1 Mar 2025

Abstract excerpt

ABSTRACT Background Aging is a known driver of chronic kidney disease (CKD), yet the genetic mechanisms linking these two conditions remain unclear. This study aims to explore the role of CD8+ central memory T (TCM) cells and their associated gene expression in the interaction between aging and CKD. Methods Peripheral blood samples from young controls, elderly individuals, and CKD patients were analyzed using...

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PMID: 40058366
DOI: 10.1002/jgm.70015

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