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Epigenetic roles in clonal hematopoiesis and aging kidney-related chronic kidney disease

20 Oct 2023

Abstract excerpt

Accumulation of somatic hematopoietic stem cell mutations with aging has been revealed by the recent genome-wide analysis. Clonal expansion, known as clonal hematopoiesis of indeterminate potential (CHIP), is a premalignant condition of hematological cancers. It is defined as the absence of definitive morphological evidence of a hematological neoplasm and occurrence of ≥2% of mutant allele fraction in the...

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PMID: 37928907
DOI: 10.3389/fcell.2023.1281850

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