Article
Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster.
G3 (Bethesda, Md.) - 8 May 2025
da Silva Ribeiro Tiago, Lollar Matthew J, Sprengelmeyer Quentin D, Huang Yuheng, Benson Derek M, Orr Megan S, Johnson Zachary C, Corbett-Detig Russell B, Pool John E
Abstract excerpt
The distribution of allelic effects on traits, along with their gene-by-gene and gene-by-environment interactions, contributes to the phenotypes available for selection and the trajectories of adaptive variants. Nonetheless, uncertainty persists regarding the effect sizes underlying adaptations and the importance of genetic interactions. Herein, we aimed to investigate the genetic architecture and the epistatic...
Topics
- Animals
- Drosophila melanogaster
- Quantitative Trait Loci
- Epistasis, Genetic
- Phenotype
- Adaptation, Physiological
- Inbreeding
- Gene-Environment Interaction
- Models, Genetic
- Pigmentation
- Quantitative Trait, Heritable
- Recombination, Genetic