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Article

Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel.

Genetics - 1 Dec 2017

Noble Luke M, Chelo Ivo, Guzella Thiago, Afonso Bruno, Riccardi David D, Ammerman Patrick, Dayarian Adel, Carvalho Sara, Crist Anna, Pino-Querido Ania, Shraiman Boris, Rockman Matthew V, Teotónio Henrique

Abstract excerpt

Understanding the genetic basis of complex traits remains a major challenge in biology. Polygenicity, phenotypic plasticity, and epistasis contribute to phenotypic variance in ways that are rarely clear. This uncertainty can be problematic for estimating heritability, for predicting individual phenotypes from genomic data, and for parameterizing models of phenotypic evolution. Here, we report an advanced...

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Identifiers

PMID: 29066469
DOI: 10.1534/genetics.117.300406
PMCID: PMC5714472

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Source receipt: pubmed, retrieved 7 Sept 2026.

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