Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo

6 Mar 2025

Abstract excerpt

The microenvironment is a rich source of new cancer targets. We thus used a targeted single-guide RNA library to screen a panel of human pancreatic cancer lines for genes uniquely affecting tumorigenesis. Here we show inactivation of the Adapter Protein complex-2 of clathrin-mediated endocytosis reduces cell growth in vitro, but completely oppositely, promotes tumor growth in vivo. In culture, loss of the complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cellular transport and secretion
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40050266
DOI: 10.1038/s41467-025-57521-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivoPMID 40050266Read ↗

An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesisSemantic proximity Read ↗

Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancerSemantic proximity Read ↗

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditionsSemantic proximity Read ↗

p62 in Cancer: Signaling Adaptor Beyond AutophagySemantic proximity Read ↗

Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cellsSemantic proximity Read ↗

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiationSemantic proximity Read ↗

Oncogenic RAS-driven α2 integrin induction under nutrient stress promotes cancer cell motilitySemantic proximity Read ↗

Kindlin-2 regulates the oncogenic activities of integrins and TGF-β in triple-negative breast cancer progression and metastasisSemantic proximity Read ↗

A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated FibroblastsSemantic proximity Read ↗

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung CancerSemantic proximity Read ↗

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas.Semantic proximity Read ↗

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.