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Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer

30 Oct 2020

Abstract excerpt

Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity and is associated with carcinogenesis, its clinical potential awaits further validation. Here, we found that AIMP2-DX2/AIMP2 expression ratio is strongly correlated...

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PMID: 33128014
DOI: 10.1038/s42003-020-01353-x

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