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Article

Frailty and cardiometabolic diseases: a bidirectional Mendelian randomisation study.

Age and ageing - 2 Nov 2022

Zhu Jiahao, Zhou Dan, Wang Jing, Yang Ye, Chen Dingwan, He Fan, Li Yingjun

Abstract excerpt

BACKGROUND: Frailty is strongly associated with cardiometabolic diseases in observational studies. However, whether the observed association reflects causality requires clarification. We performed a bidirectional Mendelian randomisation (MR) study to assess the causal relationship of frailty, measured by the frailty index (FI), with coronary artery disease (CAD), stroke and type 2 diabetes (T2D). METHODS: We...

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Source

Identifiers

PMID: 36346739
DOI: 10.1093/ageing/afac256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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