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Article

Genomewide Association Study of Simvastatin Pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Sept 2022

Mykkänen Anssi J H, Taskinen Suvi, Neuvonen Mikko, Paile-Hyvärinen Maria, Tarkiainen E Katriina, Lilius Tuomas, Tapaninen Tuija, Backman Janne T, Tornio Aleksi, Niemi Mikko

Abstract excerpt

We investigated genetic determinants of single-dose simvastatin pharmacokinetics in a prospective study of 170 subjects and a retrospective cohort of 59 healthy volunteers. In a microarray-based genomewide association study with the prospective data, the SLCO1B1 c.521T>C (p.Val174Ala, rs4149056) single nucleotide variation showed the strongest, genomewide significant association with the area under the plasma...

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Cytochrome P-450 CYP3A
Drug Transport and Resistance Mechanisms
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins and Cardiovascular Health

Liver-Specific Organic Anion Transporter 1

Organic Anion Transporters

Polymorphism, Single Nucleotide

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Identifiers

PMID: 35652242
DOI: 10.1002/cpt.2674
PMCID: PMC9540481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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