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Article

Identification of Schizophrenia-Risk Regulatory Variant rs1399178 in the Non-coding Region With Its Impact on NRF1 Binding.

CNS neuroscience & therapeutics - 1 Mar 2025

Ji Lei, Huang Bojian, Ren Decheng, Wei Xiaoxi, Liu Liangjie, Bi Yan, Li Zhiqiang, Yuan Fan, Han Ke, Li Keyi, Yang Fengping, Li Xingwang, Yu Tao, Shi Yi, He Lin, Lu Qing, He Guang

Abstract excerpt

AIMS: The challenges in identifying functional variants from genome-wide association studies (GWAS) and unraveling regulatory mechanisms in schizophrenia research persist, particularly in intronic regions. A non-coding regulatory variant, rs1399178, associated with schizophrenia risk, is identified and its impact on NRF1 binding is investigated. METHODS: This study focuses on schizophrenia GWAS risk loci, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40019038
DOI: 10.1111/cns.70275
PMCID: PMC11868986

Genes

NRF1
LRRFIP2
MLH1
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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