Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia.

doi:10.1038/mp.2011.129

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia.

Molecular psychiatry - 1 Dec 2012

Jablensky A, Angelicheva D, Donohoe G J, Cruickshank M, Azmanov D N, Morris D W, McRae A, Weickert C S, Carter K W, Chandler D, Alexandrov B, Usheva A, Morar B, Verbrugghe P L, Filipovska A, Rackham O, Bishop A R, Rasmussen K Ø, Dragovic M, Cooper M, Phillips M, Badcock J, Bramon-Bosch E, Almeida O P, Flicker L, Gill M, Corvin A, MacGregor S, Kalaydjieva L

Abstract excerpt

In a previous study, we detected a 6p25-p24 region linked to schizophrenia in families with high composite cognitive deficit (CD) scores, a quantitative trait integrating multiple cognitive measures. Association mapping of a 10 Mb interval identified a 260 kb region with a cluster of single-nucleotide polymorphisms (SNPs) significantly associated with CD scores and memory performance. The region contains two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genes, Overlapping

Share to Genetic Association Studies

Share to Mitochondrial Proteins

Share to Promoter Regions, Genetic

Share to Schizophrenia

Share to Schizophrenic Psychology

Source

Open in PubMed

Identifiers

PMID: 21968932
DOI: 10.1038/mp.2011.129

Genes

LYRM4
FARS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia.PMID 21968932Read ↗

A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia.Semantic proximity Read ↗

Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.Semantic proximity Read ↗

MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.Semantic proximity Read ↗

Examining the role of common and rare mitochondrial variants in schizophrenia.Semantic proximity Read ↗

Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression.Semantic proximity Read ↗

Allele-Specific Methylation Links Non-Coding Variant of rs2280906 to MYOM2 Regulation in SchizophreniaSemantic proximity Read ↗

A molecular pathway analysis stresses the role of inflammation and oxidative stress towards cognition in schizophrenia.Semantic proximity Read ↗

Ultrarare Coding Variants and Cognitive Function in Schizophrenia-Unraveling the Enduring Mysteries of Neuropsychiatric Genetics.Semantic proximity Read ↗

Molecular links between mitochondrial dysfunctions and schizophrenia.Semantic proximity Read ↗

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.Semantic proximity Read ↗

Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation.Semantic proximity Read ↗

Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.