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Article

Use of HSALR female mice as a model for the study of myotonic dystrophy type I.

Lab animal - 1 Apr 2025

Carrascosa-Sàez Marc, Colom-Rodrigo Anna, González-Martínez Irene, Pérez-Gómez Raquel, García-Rey Andrea, Piqueras-Losilla Diego, Ballestar Ana, Llamusí Beatriz, Cerro-Herreros Estefanía, Artero Ruben

Abstract excerpt

HSALR mice are the most broadly used animal model for studying myotonic dystrophy type I (DM1). However, so far, HSALR preclinical studies have often excluded female mice or failed to document the biological sex of the animals. This leaves an unwanted knowledge gap concerning the differential development of DM1 in males and females, particularly considering that the disease has a different clinical presentation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40016516
DOI: 10.1038/s41684-025-01506-7
PMCID: PMC11957995

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