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Article

Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo

30 Jan 2024

Abstract excerpt

Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in the detrimental inflammation caused by SARS-CoV-2 infection. We minimally and extensively passaged a single clinical SARS-CoV-2 isolate to create models of mild and severe disease in mice allowing us to dissect the role of necroptosis in SARS-CoV-2 disease pathogenesis. We infected...

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PMID: 38286985
DOI: 10.1038/s41419-024-06471-6

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