Article
Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners.
Mutation research - 1 Jan 2000
Tanaka K, Ino T, Sawahata T, Marui S, Igaki H, Yashima H
Abstract excerpt
3 epoxy-resin hardeners, 4,4'-diaminodiphenyl ether (DDE), 4,4'-diaminodiphenylmethane (DDM), and 4,4'-diaminodiphenylsulfone (DDS), and their N-acetyl and N,N'-diacetyl derivatives were examined for their mutagenicity using Salmonella typhimurium TA98 and TA100 as the tester stains and an S9 mix containing a rat-liver 9000 X g supernatant fraction as the metabolic activation system. DDE and DDM were mutagenic...
Topics
- Aniline Compounds
- Animals
- Biotransformation
- Dapsone
- Epoxy Resins
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutation
- Phenyl Ethers
- Rats
- Rats, Inbred Strains