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Article

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.

Genes & development - 15 Feb 2003

Pothof Joris, van Haaften Gijs, Thijssen Karen, Kamath Ravi S, Fraser Andrew G, Ahringer Julie, Plasterk Ronald H A, Tijsterman Marcel

Abstract excerpt

An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly...

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Identifiers

PMID: 12600937
DOI: 10.1101/gad.1060703
PMCID: PMC195995

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