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Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

23 Feb 2025

Abstract excerpt

Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells, reverses telomere erosion. We have previously observed that transient transfection with human TERT mRNA extends telomeres and mitigates hallmarks of senescence in replicatively aged human cells or those affected by Hutchinson-Gilford progeroid syndrome (HGPS). However, due to its...

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PMID: 39988827
DOI: 10.1111/acel.70021

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