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Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

22 Jan 2015

Abstract excerpt

Telomere extension has been proposed as a means to improve cell culture and tissue engineering and to treat disease. However, telomere extension by nonviral, nonintegrating methods remains inefficient. Here we report that delivery of modified mRNA encoding TERT to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly extends telomeres, after which telomeres resume...

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PMID: 25614443
DOI: 10.1096/fj.14-259531

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