Telomere uncapping and vascular aging

Abstract excerpt

Although most telomere biology research continues to focus on telomere shortening, there is increasing evidence that telomere deprotection, or "uncapping," is more biologically and possibly clinically important. Telomeres form t-loops to prevent the chromosome ends from appearing as a double-stranded DNA break and initiating a DNA damage response. Breakdown of the t-loop structure, referred to as uncapping, can...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Telomeres, Telomerase, and Senescence