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Article

SOX10-Mediated Regulation of Enteric Glial Phenotype in vitro and its Relevance for Neuroinflammatory Disorders.

Journal of molecular neuroscience : MN - 21 Feb 2025

Kunke Madlen, Kaehler Meike, Boni Sebastien, Schröder Katja, Weier Alicia, Chunder Rittika, Kuerten Stefanie, Böttner Martina, Cascorbi Ingolf, Neunlist Michel, Wedel Thilo, Lucius Ralph, Cossais François

Abstract excerpt

The transcription factor SOX10 is a key regulator of myelinated glial cell phenotype and function, with a known role in multiple sclerosis (MS). SOX10 is also expressed in enteric glial cells (EGC) within the gut, yet its regulatory functions in EGC remain poorly understood. This study aimed to identify SOX10 target genes that influence EGC phenotype and may have implications for MS. An EGC cell line was...

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Topics

SOXE Transcription Factors
Neuroglia
Humans
Cell Line
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neuroinflammatory Diseases

Enteric Nervous System

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 39982575
DOI: 10.1007/s12031-025-02321-y
PMCID: PMC11845537

Genes

SOX10
PLP1
APOD
NES
RNF130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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