Article

Single Cell Profiling in the <i> Sox10 <sup>Dom/+</sup> </i> Hirschsprung Mouse Implicates <i>Hoxa6</i> in Enteric Neuron Lineage Allocation

2024-09-19

Abstract excerpt

<h4>Background & Aims</h4> Enteric nervous system (ENS) development requires migration, proliferation, and appropriate neuronal diversification from progenitors to enable normal gastrointestinal (GI) motility. Sox10 deficit causes aganglionosis, modeling Hirschsprung disease, and disrupts ratios of postnatal enteric neurons in proximal ganglionated bowel. How Sox10 deficiency alters ratios of enteric neuron sub...

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Literature Corpus work: 304966ee-cb02-5ac0-93c2-b99902cb301d
DOI: 10.1101/2024.09.18.613729

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