Article
Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies.
Investigative ophthalmology & visual science - 3 Feb 2025
Moekotte Lude, de Boer Joke H, Hiddingh Sanne, de Ligt Aafke, Nguyen Xuan-Thanh-An, Hoyng Carel B, Inglehearn Chris F, McKibbin Martin, Lamey Tina M, Thompson Jennifer A, Chen Fred K, McLaren Terri L, AlTalbishi Alaa, Panneman Daan M, Boonen Erica G M, Banfi Sandro, Bocquet Béatrice, Meunier Isabelle, De Baere Elfride, Koenekoop Robert, Oldak Monika, Rivolta Carlo, Roberts Lisa, Ramesar Raj, Strupaite-Šileikiene Rasa, Kohl Susanne, Farrar G Jane, van Vugt Marion, van Setten Jessica, Roosing Susanne, van den Born L Ingeborgh, Boon Camiel J F, van Genderen Maria M, Kuiper Jonas J W
Abstract excerpt
Purpose: To determine the profile of inflammation-related proteins and complement system factors in the plasma of CRB1-associated inherited retinal dystrophies (CRB1-IRDs). Methods: We used the Olink Explore 384 Inflammation II panel for targeted proteomics in 30 cases and 29 controls (cohort I) to identify immune pathways involved in CRB1-IRDs. Genotyping was performed in cohort I and a second cohort of 123...
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