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Complement System Proteins in the Human Aqueous Humor and Their Association with Primary Open-Angle Glaucoma

19 Sept 2023

Abstract excerpt

This study discovers the complement protein profile in the aqueous humor (AH) of human subjects and investigates its association with primary open-angle glaucoma (POAG) pathogenesis. Among the 32 complement proteins identified, 22 were highly abundant and detected in more than 50% of AH samples. The most predominant active complement proteins in the AH are C3, C4B, C4A, CFB, CFD, and C9. Additionally, the most...

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PMID: 37763167
DOI: 10.3390/jpm13091400

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