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Unveiling Inflammation-Like Retinal Remodeling in CRB1-Associated Inherited Retinal Dystrophies: Insights From a Multicenter Study.

American journal of ophthalmology - 1 Feb 2026

Hong Yu, Li Jianqing, Chen Zhixuan, Zhang Ting, Chen Minghao, Hang Chenyue, Liu Xinxin, Sun Junran, Li Tong, Jia Huixun, Xiong Jian, Lin Bing, Liu Xing, Chen Jieqiong, Sun Xiaodong

Abstract excerpt

PURPOSE: To delineate the intricate interplay between inflammation, retinal remodeling, and genotype in CRB1-associated inherited retinal diseases (CRB1-IRDs). DESIGN: Retrospective, multicenter observational case series. METHODS: We evaluated 66 CRB1-retinopathy patients from 61 unrelated families recruited from 4 tertiary hospitals in China between June 2016 and July 2024. Comprehensive medical records,...

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Identifiers

PMID: 41242591
DOI: 10.1016/j.ajo.2025.11.008

Genes

CRB1

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