Article
The Role of Protein Z and Protein Z-Dependent Protease Inhibitor Polymorphisms in the Development of Prosthetic Heart Valve Thrombosis.
The Journal of heart valve disease - 1 Jul 2017
Karakoyun Süleyman, Ozan Gürsoy Mustafa, Kalçık Macit, Yesin Mahmut, Gündüz Sabahattin, Ali Astarcıoğlu Mehmet, Bayram Zübeyde, Çakal Beytullah, Bayam Emrah, Özkan Mehmet
Abstract excerpt
BACKGROUND AND AIM OF THE STUDY: Protein Z (PZ) is a vitamin K-dependent factor that is synthesized mainly by the liver. It acts as an activator of serpin, the protein Z-dependent inhibitor (ZPI), which inhibits factor Xa. The potential role of alterations in protein Z and/or ZPI levels in the pathogenesis of thrombotic and/or hemorrhagic diseases has been previously investigated, but results have been...
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