Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations within the protein Z‐dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia

1 Oct 2004

Abstract excerpt

Protein Z-dependent protease inhibitor (ZPI) is a serpin that inhibits the activated coagulation factors X and XI. The precise physiological significance of ZPI in the control of haemostasis is unknown although a deficiency of ZPI may be predicted to alter this balance. The coding region of the ZPI gene was screened for mutations using denaturing high-performance liquid chromatography. 16 mutations/polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Protease and Inhibitor Mechanisms
Share to Venous Thromboembolism Diagnosis and Management

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15461625
DOI: 10.1111/j.1365-2141.2004.05189.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations within the protein Z‐dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophiliaPMID 15461625Read ↗

Two missense mutations identified in venous thrombosis patients impair the inhibitory function of the protein Z dependent protease inhibitor.Semantic proximity Read ↗

A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis.Semantic proximity Read ↗

The Role of Protein Z and Protein Z-Dependent Protease Inhibitor Polymorphisms in the Development of Prosthetic Heart Valve Thrombosis.Semantic proximity Read ↗

Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.Semantic proximity Read ↗

Plasma concentration of protein Z-dependent protease inhibitor and ZPI exon 3 mutations in preeclampsia.Semantic proximity Read ↗

Thrombotic risk determined by rare and common SERPINA1 variants in a population-based cohort study.Semantic proximity Read ↗

Low protein Z levels and risk of occurrence of deep vein thrombosis.Semantic proximity Read ↗

[Protein Z: a new regulator of coagulation in arterial vessels?].Semantic proximity Read ↗

Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis.Semantic proximity Read ↗

Tapping Into the Natural PZ-Independent Anticoagulant Function of ZPI to Inhibit Thrombosis With Minimal Effect on Hemostasis.Semantic proximity Read ↗

α1 -Antitrypsin Z allele and risk of venous thromboembolism in the general population.Semantic proximity Read ↗

Protein Z, an anticoagulant protein with expanding role in reproductive biology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.