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Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes: KORA F4/FF4 cohort study.

Cardiovascular diabetology - 19 Feb 2025

Huemer Marie-Theres, Spagnuolo Maria C, Maalmi Haifa, Wagner Robert, Bönhof Gidon J, Heier Margit, Koenig Wolfgang, Rathmann Wolfgang, Prystupa Katsiaryna, Nano Jana, Ziegler Dan, Peters Annette, Roden Michael, Thorand Barbara, Herder Christian

Abstract excerpt

BACKGROUND: Using a data-driven approach, six clusters with different risk profiles and burden of complications were recently identified in middle-aged people before the diagnosis of type 2 diabetes (T2D). We aimed to investigate whether these clusters could be generalised to older people and if subclinical inflammation was related to their cardiometabolic risk profiles. METHODS: We assigned 843 participants of...

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Identifiers

PMID: 39972466
DOI: 10.1186/s12933-025-02617-8
PMCID: PMC11841139

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