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Article

Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases.

Expert review of clinical immunology - 1 Feb 2014

Pelham Christopher J, Agrawal Devendra K

Abstract excerpt

Innate immune receptors represent important therapeutic targets for inflammatory disorders. In particular, the Toll-like receptor (TLR) family has emerged as a promoter of chronic inflammation that contributes to obesity, insulin resistance and atherosclerosis. Importantly, triggering receptor expressed on myeloid cells-1 (TREM-1) has been characterized as an 'amplifier' of TLR2 and TLR4 signaling. TREM-1- and...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Immune System Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Membrane Glycoproteins

Share to Receptor Cross-Talk

Share to Receptors, Immunologic

Share to Toll-Like Receptor 2

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Source

Identifiers

PMID: 24325404
DOI: 10.1586/1744666X.2014.866519

Genes

TLR2
TLR4
TREML1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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