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Article

A mutation in Tmem135 causes progressive sensorineural hearing loss.

Hearing research - 1 Apr 2025

Kim Mi-Jung, Simms Shion, Behnammanesh Ghazaleh, Chen Wei-Wen, Honkura Yohei, Suzuki Jun, Park Hyo-Jin, Milani Marcus, Katori Yukio, Bird Jonathan E, Ikeda Akihiro, Someya Shinichi

Abstract excerpt

Transmembrane protein 135 (TMEM135) is a highly conserved 52 kDa protein with five predicted transmembrane domains that colocalizes with mitochondria and peroxisomes. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism across multiple tissues and species; however, its role in the inner ear and auditory system remains unknown. We investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39970612
DOI: 10.1016/j.heares.2025.109221
PMCID: PMC12171014

Genes

TMEM135
ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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