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Article

A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.

Scientific reports - 14 Jan 2022

Landowski Michael, Bhute Vijesh J, Takimoto Tetsuya, Grindel Samuel, Shahi Pawan K, Pattnaik Bikash R, Ikeda Sakae, Ikeda Akihiro

Abstract excerpt

Aging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we further our studies on transmembrane protein 135 (Tmem135), a gene involved in retinal aging, by examining the transcriptomic profiles of wild-type, heterozygous and homozygous Tmem135 mutant posterior eyecup samples through RNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35031662
DOI: 10.1038/s41598-021-04644-3
PMCID: PMC8760256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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