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Slc16a5 (MCT6) knockout induces sex-dependent changes in auditory function, hair cell viability and cochlear transcriptomic programs in the mouse.

Hearing research - 1 Sept 2026

Germakovski Arthur, Ye Mengxiao, Chen Guang-Di, Li Li, Marzullo Brandon, Sun Wei, Sprowl Jason A, Hu Bo Hua

Abstract excerpt

The maintenance of cochlear homeostasis requires precise metabolic regulation, yet the specific roles of monocarboxylate transporters in auditory function remain poorly understood. Monocarboxylate transporter 6 (Mct6), encoded by Slc16a5, is a membrane transporter of the solute carrier 16 family involved in the cellular transport of metabolites related to energy metabolism and signaling. Here, we investigated the...

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PMID: 42364554
DOI: 10.1016/j.heares.2026.109711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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