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Article

Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.

Investigative ophthalmology & visual science - 1 Oct 2020

Landowski Michael, Grindel Samuel, Shahi Pawan K, Johnson Abigail, Western Daniel, Race Adrienne, Shi Franky, Benson Jonathan, Gao Marvin, Santoirre Evelyn, Lee Wei-Hua, Ikeda Sakae, Pattnaik Bikash R, Ikeda Akihiro

Abstract excerpt

Purpose: Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Overexpression of Tmem135 causes mitochondrial fragmentation and pathologies in the hearts of mice. In this study, we...

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Identifiers

PMID: 33064130
DOI: 10.1167/iovs.61.12.16
PMCID: PMC7581492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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