Article

Methionine sulfoxide reductase B3 antioxidant activity is indispensable for mouse inner ear cuticular plate structure and hair bundle integrity

2025-03-10

Abstract excerpt

Methionine sulfoxide reductases (MSR) are enzymes responsible for catalyzing the reduction of methionine-sulfoxides. We previously demonstrated that variants in human MSRB3 , a member of the MSR family, are associated with profound autosomal recessive prelingual non-syndromic hearing loss DFNB74. To better understand the role of MSRB3 in the auditory pathway, we generated a complete MsrB3 gene knock-out mouse mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8c5cf0e-2a25-53e8-b856-d4489da3d10a
DOI: 10.1101/2025.03.04.641487

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methionine sulfoxide reductase B3 antioxidant activity is indispensable for mouse inner ear cuticular plate structure and hair bundle integrityDOI 10.1101/2025.03.04.641487Read

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.Semantic proximity Read

Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.Semantic proximity Read

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia MaintenanceSemantic proximity Read

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stressSemantic proximity Read

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress.Semantic proximity Read

Mouse models of age-related mitochondrial neurosensory hearing loss.Semantic proximity Read

Endogenous SIRT3 activity is dispensable for normal hearing recovery after noise exposure in young adult miceSemantic proximity Read

Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.Semantic proximity Read

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing lossSemantic proximity Read

Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization.Semantic proximity Read

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function.Semantic proximity Read

A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIASemantic proximity Read