Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Research progress on Nrf2 intervention in the treatment of diabetic retinopathy

21 May 2025

Abstract excerpt

Diabetic retinopathy (DR) is a primary cause of vision loss among individuals with diabetes and represents the most prevalent microvascular complication of diabetes mellitus. Its pathophysiological mechanisms involve processes such as oxidative stress, chronic inflammation, cell apoptosis, and angiogenesis. As a core transcription factor in the antioxidant response, Nrf2 upregulates the expression of antioxidant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Glycation End Products research
Share to Heme Oxygenase-1 and Carbon Monoxide
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40469432
DOI: 10.3389/fendo.2025.1587231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Research progress on Nrf2 intervention in the treatment of diabetic retinopathyPMID 40469432Read ↗

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An UpdateSemantic proximity Read ↗

Regulatory factors of Nrf2 in age-related macular degeneration pathogenesisSemantic proximity Read ↗

Advances in the Molecular Pathophysiology and Emerging Therapeutic Strategies for Diabetic RetinopathySemantic proximity Read ↗

Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic EncephalopathySemantic proximity Read ↗

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic CardiomyopathySemantic proximity Read ↗

Diabetic Retinopathy: New Treatment Approaches Targeting Redox and Immune MechanismsSemantic proximity Read ↗

Flotillin-1 as a housekeeping target mediates Nrf2 inhibition of blood–retinal barrier ferroptosis in diabetic retinopathySemantic proximity Read ↗

The Unfolded Protein Response and Diabetic RetinopathySemantic proximity Read ↗

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic TargetSemantic proximity Read ↗

An Association between Bilirubin and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: An Effect Modification by Nrf2 Polymorphisms.Semantic proximity Read ↗

Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A ReviewSemantic proximity Read ↗

Diabetic retinopathy is associated with oxidative stress and mitigation of gene expression of antioxidant enzymesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.