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Recent developments in the study of cellular inflammation in the papillae of stone formers.

Urolithiasis - 17 Feb 2025

Williams James C, El-Achkar Tarek M

Abstract excerpt

Kidney stone disease has long been thought to involve tissue inflammation, but direct evidence linking inflammation as a causative factor in human stone formation remains limited. This review focuses on studies in human stone formers, highlighting variation in stone former phenotypes. Histological and molecular studies of kidney tissues reveal increased immune cell density and gene expression changes in stone...

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PMID: 39960517
DOI: 10.1007/s00240-025-01707-2

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