Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KDM5C and KDM5D mutations have different consequences in clear cell renal cell carcinoma cells

15 Feb 2025

Abstract excerpt

KDM5C is commonly mutated in clear cell renal cell carcinomas (ccRCC) in men but rarely in women. Introducing KDM5C mutation into two male and two female KDM5C wild-type ccRCC cell lines caused different phenotypes and non-overlapping transcriptional consequences, indicative of context-dependent functions of KDM5C. We identify that loss of the Y chromosome, harbouring the KDM5C homologue KDM5D, occurs in most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39955388
DOI: 10.1038/s42003-025-07695-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KDM5C and KDM5D mutations have different consequences in clear cell renal cell carcinoma cellsPMID 39955388Read ↗

Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinomaSemantic proximity Read ↗

Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC).Semantic proximity Read ↗

Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinomaSemantic proximity Read ↗

Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma.Semantic proximity Read ↗

An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC).Semantic proximity Read ↗

CDCA5 is a potent therapeutic target of clear cell renal cell carcinomaSemantic proximity Read ↗

Loss of PBRM1 expression is associated with renal cell carcinoma progression.Semantic proximity Read ↗

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cellsSemantic proximity Read ↗

Cooperation and antagonism among cancer genes: the renal cancer paradigm.Semantic proximity Read ↗

Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

FOXD1 regulates cell division in clear cell renal cell carcinomaSemantic proximity Read ↗

Downregulation of WDR 20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.