Article

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Clear cell renal cell carcinoma (ccRCC) arises more frequently in men than in women, but it remains unclear why this is the case. Mouse models that mimic the truncal mutation of the two most commonly affected tumor suppressor genes in human ccRCC revealed that the transcriptional effects of Vhl or Vhl/Pbrm1 mutation in male and female proximal tubule cells only partially overlap. Cellular resp...

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Literature Corpus work: 37c512c8-6a87-5b3f-9a2c-72fdbe4e2193
DOI: 10.64898/2026.05.22.727114

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