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Article

Cooperation and antagonism among cancer genes: the renal cancer paradigm.

Cancer research - 15 Jul 2013

Peña-Llopis Samuel, Christie Alana, Xie Xian-Jin, Brugarolas James

Abstract excerpt

It is poorly understood how driver mutations in cancer genes work together to promote tumor development. Renal cell carcinoma (RCC) offers a unique opportunity to study complex relationships among cancer genes. The four most commonly mutated genes in RCC of clear-cell type (the most common type) are two-hit tumor suppressor genes, and they cluster in a 43-Mb region on chromosome 3p that is deleted in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23832661
DOI: 10.1158/0008-5472.CAN-13-0360
PMCID: PMC4051157

Genes

PBRM1
BAP1
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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