Article
An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC).
BMC genomics - 22 Aug 2016
Wang Yuanyuan, Guo Xingyi, Bray Michael J, Ding Zhiyong, Zhao Zhongming
Abstract excerpt
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Recent large-scale next-generation sequencing analyses reveal that PBRM1 is the second most frequently mutated gene harboring many truncated mutations and has a suspected tumor suppressor role in ccRCC. However, the biological consequences of PBRM1 somatic mutations (e.g., truncated mutations) that drive tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.