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Downregulation of WDR 20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma

20 Jan 2016

Abstract excerpt

Previously, we reported that genomic loss of 14q occurs more frequently in high-grade than in low-grade clear cell renal cell carcinomas (ccRCCs), and has a significant impact on the levels of expression of genes located in this region, suggesting that such genes may be involved in the malignant transformation of ccRCCs. Here, we found that six of the genes located in the minimal common region of 14q loss were...

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PMID: 26790128
DOI: 10.1111/cas.12892

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