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Article

Clinicopathologic and genomic analyses of SMARCA4-mutated non-small cell lung carcinoma implicate the needs for tailored treatment strategies.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2025

Ahn Bokyung, Kim Deokhoon, Ji Wonjun, Chun Sung-Min, Lee Goeun, Jang Se Jin, Hwang Hee Sang

Abstract excerpt

BACKGROUND: The clinicopathologic and therapeutic significance of SMARCA4 mutation in non-small cell lung carcinoma (NSCLC) remains unclear. METHODS: We retrieved 575 NSCLC cases from the clinical target sequencing cohort (N = 2157) to compare the clinicopathologic characteristics of groups subclassified based on the presence of truncated or non-truncated SMARCA4 mutations (SMARCA4-truncated,...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Male
DNA Helicases
Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Female

Middle Aged

Aged

Prognosis

Biomarkers, Tumor

Genomics

Gene Expression Profiling

Source

Identifiers

PMID: 39954349
DOI: 10.1016/j.lungcan.2025.108445

Genes

SMARCA4
MAGEA4
PRAME

Provenance

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