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Article

SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.

Pathology - 1 Jun 2024

Cheung Alvin Ho-Kwan, Wong Kit-Yee, Chau Shuk-Ling, Xie Fuda, Mui Zeta, Li Gordon Yuan-Ho, Li Molly Siu Ching, Tong Joanna, Ng Calvin Sze-Hang, Mok Tony S, Kang Wei, To Ka-Fai

Abstract excerpt

SMARCA4 mutation has emerged as a marker of poor prognosis in lung cancer and has potential predictive value in cancer treatment, but recommendations for which patients require its investigation are lacking. We comprehensively studied SMARCA4 alterations and the clinicopathological significance in a large cohort of immunohistochemically-subtyped non-small cell lung cancer (NSCLC). A total of 1416 patients was...

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PMID: 38413251
DOI: 10.1016/j.pathol.2023.12.414

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