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Article

Rare SMARCA4-deficient thoracic tumor: Insights into molecular characterization and optimal therapeutics methods.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2024

Shi Mengting, Pang Lanlan, Zhou Huaqiang, Mo Silang, Sheng Jin, Zhang Yaxiong, Liu Jiaqing, Sun Dongchen, Gong Longlong, Wang Jiawei, Zhuang Weitao, Huang Yihua, Chen Zihong, Zhao Yuanyuan, Li Jing, Huang Yan, Yang Yunpeng, Fang Wenfeng, Zhang Li

Abstract excerpt

INTRODUCTIONS: The 2021 WHO Classification of Thoracic Tumors recognized SMARCA4-deficient undifferentiated thoracic tumors (SMARCA4-dUT) as a distinct entity that shows a striking overlap in demographic and molecular profiles with SMARCA4-deficient non-small lung cancer (SMARCA4-dNSCLC). The implications of SMARCA4 deficiency based on immunohistochemistry remain unclear. We aimed to investigate molecular...

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Identifiers

PMID: 38763102
DOI: 10.1016/j.lungcan.2024.107818

Genes

SMARCA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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