Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in homologous recombination repair genes in patients with metastatic endometrial cancer: association with clinical characteristics and prognosis.

Journal of gynecologic oncology - 1 Jul 2025

Zhong Ling, Lin Ying, Li Chunxiao, Qian Haili, Shen Minghong

Abstract excerpt

OBJECTIVE: To evaluate the mutation rates of homologous recombination repair (HRR) genes and the impact of these mutations on the clinical characteristics of metastatic endometrial cancer (EC). METHODS: Somatic DNA from 895 patients with metastatic EC in the Memorial Sloan Kettering-Metastatic Events and Tropisms cohort was assessed for mutations in 10 HRR genes (BRCA1, BRCA2, ATM, BARD1, BRIP1, PALB2, RAD51C,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Endometrioid

Share to Endometrial Neoplasms

Share to Mutation

Share to Neoplasm Metastasis

Share to Prognosis

Share to Recombinational DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 39950607
DOI: 10.3802/jgo.2025.36.e62
PMCID: PMC12226326

Genes

ATM
BARD1
BRCA1
BRCA2
BRIP1
CDK12
CHEK2
PALB2
POLE
RAD51C
RAD51D
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in homologous recombination repair genes in patients with metastatic endometrial cancer: association with clinical characteristics and prognosis.PMID 39950607Read ↗

The genomic landscape of distant metastatic endometrial cancer.Semantic proximity Read ↗

Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma.Semantic proximity Read ↗

Homologous recombination deficiency gene panel analysis results in synchronous endometrial and ovarian cancers.Semantic proximity Read ↗

Molecular Classification of Endometrial Cancer and Its Impact on Therapy Selection.Semantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Next generation sequencing reveals a high prevalence of pathogenic mutations in homologous recombination DNA damage repair genes among patients with uterine sarcoma.Semantic proximity Read ↗

Molecular typing guiding treatment and prognosis of endometrial cancerSemantic proximity Read ↗

Mutation profile and molecular heterogeneity in mismatch repair deficient endometrial carcinomaSemantic proximity Read ↗

Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutationSemantic proximity Read ↗

Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer.Semantic proximity Read ↗

Met Mutation is a Potential Therapeutic Target for Advanced Endometrial Cancer Semantic proximity Read ↗

Impact of molecular profile on prognosis and relapse pattern in low and intermediate risk endometrial cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.