Article
The genomic landscape of distant metastatic endometrial cancer.
Gynecologic oncology - 1 Apr 2025
Zammarrelli William A, Nandakumar Subhiksha, Kertowidjojo Elizabeth, Nguyen Bastien, Moukarzel Lea A, Da Cruz Paula Arnaud, Rios-Doria Eric V, Smith Shaleigh A, Momeni-Boroujeni Amir, Makker Vicky, Aghajanian Carol, Chatila Walid K, Mueller Jennifer J, Abu-Rustum Nadeem R, Schultz Nikolaus, Ellenson Lora H, Weigelt Britta
Abstract excerpt
OBJECTIVE: The molecular underpinnings of primary treatment-naïve endometrial carcinoma (EC) are well described. Here we sought to characterize the genomic landscape of distant metastatic EC. METHODS: Distant metastatic ECs from a total of 1888 cases subjected to a clinical panel sequencing between 4/2015 and 6/2020 were identified, and their genomic profiles, affected pathways and actionable alterations were...
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