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Article

Next generation sequencing reveals a high prevalence of pathogenic mutations in homologous recombination DNA damage repair genes among patients with uterine sarcoma.

Gynecologic oncology - 1 Oct 2023

Nasioudis Dimitrios, Latif Nawar A, Ko Emily M, Cory Lori, Kim Sarah H, Martin Lainie, Simpkins Fiona, Giuntoli Robert

Abstract excerpt

OBJECTIVE: Investigate the incidence of homologous recombination DNA damage response (HR-DDR) genomic alterations among patients with uterine sarcoma. METHODS: The American Association for Cancer Research GENIE v13.0 database was accessed and patients with uterine leiomyosarcoma, adenosarcoma, undifferentiated uterine sarcoma, high-grade endometrial stromal sarcoma, low-grade endometrial stromal sarcoma, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37611378
DOI: 10.1016/j.ygyno.2023.07.020

Genes

ATRX
BRCA2
RAD51B
ARID1A
ATM
BAP1
BARD1
BLM
BRCA1
BRIP1
CHEK1
CHEK2
FANCA
FANCC
FANCD2
FANCE
FANCF
FANCG
FANCL
MRE11
NBN
PALB2
RAD50
RAD51
RAD51C
RAD51D
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Next generation sequencing reveals a high prevalence of pathogenic mutations in homologous recombination DNA damage repair genes among patients with uterine sarcoma.PMID 37611378Read ↗

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Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.Semantic proximity Read ↗

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