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STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein

13 Feb 2025

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV), a highly pathogenic enteric coronavirus, has caused significant economic losses worldwide in recent years. The PEDV spike (S) protein has been reported to undergo extensive N-glycosylation, suggesting that glycosylation plays a crucial role in PEDV replication. In this study, we demonstrated that the N-glycosylation pathway promotes PEDV replication by facilitating the...

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PMID: 39945486
DOI: 10.1128/jvi.00018-25

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