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Modification of N-glycosylation site in the spike protein enhances the neutralizing antibody response against PEDV.

Veterinary microbiology - 1 May 2026

Pan Shuonan, Wei Liping, Xiang Yingjie, Mou Chunxiao, Liu Huili, Chen Zhenhai

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) is a pathogenic enteric coronavirus of swine that causes severe diarrhea and high mortality in neonatal piglets. The extensively glycosylated spike (S) protein is essential for viral entry and vaccine design. For comprehensively characterizing N-glycosylation modifications of S protein, we analyzed the S proteins of 152 PEDV strains, revealing that the average number of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41793877
DOI: 10.1016/j.vetmic.2026.110972

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