Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The glycosylation sites in RBD of spike protein attenuate the immunogenicity of PEDV AH2012/12

2 May 2024

Abstract excerpt

Porcine epidemic diarrhea (PED) is a highly contagious swine intestinal disease caused by PED virus (PEDV). Vaccination is a promising strategy to prevent and control PED. Previous studies have confirmed that glycosylation could regulate the immunogenicity of viral antigens. In this study, we constructed three recombinant PEDVs which removed the glycosylation sites in RBD. Viral infection assays revealed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38679392
DOI: 10.1016/j.virusres.2024.199381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The glycosylation sites in RBD of spike protein attenuate the immunogenicity of PEDV AH2012/12PMID 38679392Read ↗

Modification of N-glycosylation site in the spike protein enhances the neutralizing antibody response against PEDV.Semantic proximity Read ↗

N-glycosylation of the PEDV spike protein modulates viral replication and pathogenicitySemantic proximity Read ↗

Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2.Semantic proximity Read ↗

A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein.Semantic proximity Read ↗

Bioinformatics Analysis of Spike Proteins of Porcine Enteric CoronavirusesSemantic proximity Read ↗

Biological Characteristics and Pathogenicity Analysis of a Low Virulence G2a Porcine Epidemic Diarrhea VirusSemantic proximity Read ↗

Isolation and characterization of porcine epidemic diarrhea virus with mutations in the spike gene in China.Semantic proximity Read ↗

Immunogenicity and protective efficacy of recombinant adenovirus expressing a novel genotype G2b PEDV spike protein in protecting newborn piglets against PEDV.Semantic proximity Read ↗

Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy.Semantic proximity Read ↗

Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusSemantic proximity Read ↗

The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge.Semantic proximity Read ↗

Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.