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N-glycosylation of the PEDV spike protein modulates viral replication and pathogenicity

29 Aug 2025

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV), a highly virulent enteric coronavirus, induces severe watery diarrhea and mortality in suckling piglets. The spike (S) protein, a critical mediator of viral entry, undergoes extensive N-linked glycosylation. To elucidate the functional significance of these post-translational modifications, we employed a reverse genetics system to generate 19 recombinant PEDV strains with...

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PMID: 40883772
DOI: 10.1186/s13567-025-01606-9

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