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Article

LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase.

Molecular biology of the cell - 1 Apr 2025

Doray Baraj, Jennings Benjamin C, Yang Xi, Liu Lin, Venkatarangan Varsha, Kornfeld Stuart, Li Ming

Abstract excerpt

LYSET is a recently identified Golgi transmembrane (TM) protein, and inactivating mutations in the LYSET gene phenocopy mucolipidosis II (MLII), the lysosomal storage disease caused by loss of function of GlcNAc-1-phosphotransferase αβ (GNPTαβ), which tags lysosomal hydrolases with the mannose 6-phosphate (M6P) tag for delivery to lysosomes. It is conceivable that LYSET facilitates integration of both hydrophilic...

Read the complete abstract on PubMed

Topics

Humans
Golgi Apparatus
Transferases (Other Substituted Phosphate Groups)
Protein Domains
Lysosomes
Mucolipidoses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Membrane Proteins

HEK293 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 39937677
DOI: 10.1091/mbc.E24-08-0349
PMCID: PMC12005095

Genes

LYSET

Provenance

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